Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Escherichia Coli
SUBMITTER: Egor Vorontsov
LAB HEAD: Dan I. Andersson
PROVIDER: PXD005236 | Pride | 2018-05-11
REPOSITORIES: Pride
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Nature ecology & evolution 20180528 8
One key concept in the evolution of new functions is the ability of enzymes to perform promiscuous side-reactions that serve as a source of novelty that may become beneficial under certain conditions. Here, we identify a mechanism where a bacteriophage-encoded enzyme introduces novelty by inducing expression of a promiscuous bacterial enzyme. By screening for bacteriophage DNA that rescued an auxotrophic Escherichia coli mutant carrying a deletion of the ilvA gene, we show that bacteriophage-enc ...[more]