Proteomics

Dataset Information

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Proteomic characterization of stem cell-derived extracellular matrices


ABSTRACT: We characterized and compared the proteomic composition of ECM produced in vitro by bone marrow-derived MSC, adipose-derived MSC and neonatal fibroblasts isolated from different donors, employing a multidimensional proteomic approach coupled with label-based quantitative proteomics. Each cell-derived ECM displayed a specific and unique matrisome signature, yet they all shared a common set of proteins. We evaluated the biological response of cells cultured on the different matrices and compared them to cells on standard TCPS. The matrices lead to differential proliferation and gene expression profiles between the cell types and as compared to TCPS, indicating that the cell-derived ECM influence each cell type in a unique manner.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Embryonic Stem Cell

SUBMITTER: Amanda Del Rosario  

LAB HEAD: Amanda Del Rosario

PROVIDER: PXD005521 | Pride | 2017-03-08

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
150219_122_HR_BM001.mgf Mgf
150219_122_HR_BM001.mzid.gz Mzid
150219_122_HR_BM001.pride.mgf.gz Mgf
150219_122_HR_BM001.pride.mztab.gz Mztab
150219_122_HR_BM001.raw Raw
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