Dataset Information

Mouse retina LC-MSMS - Diurnal expression of proteins in the retina of the blind cone-rod homeobox (Crx(-/-) ) mouse and the 129/Sv mouse: a proteomic study

ABSTRACT: To investigate the role of the circadian clock of the photoreceptor cells in regulation of retinal protein rhythms, we have analyzed diurnal protein expression in the photoreceptor-deficient cone-rod homeobox knock out mouse (Crx-/-). Retinal homogenates of 129/sv and Crx-/- mice were analysed by 2D-PAGE. Differentially expressed spots were in-gel digested with trypsin and identified by LC-MS/MS. Data were used to search the Swiss-Prot protein database.

INSTRUMENT(S): Q-Tof Premier

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retina

SUBMITTER: Bent Honoré

LAB HEAD: Bent Honoré

PROVIDER: PXD005556 | Pride | 2017-04-04

REPOSITORIES: Pride

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			Action	DRS
	031012_10_MMoller_4213.raw.zip	Raw
	031012_10_MMoller_4213.webarchive	Other
	031012_10_MMoller_4213_CID.pkl	Other
	031012_11_MMoller_4513.raw.zip	Raw
	031012_11_MMoller_4513.webarchive	Other

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Diurnal expression of proteins in the retina of the blind cone-rod homeobox (Crx<sup>-/-</sup> ) mouse and the 129/Sv mouse: a proteomic study.

Møller Morten M Rath Martin Fredensborg MF Ludvigsen Maja M Honoré Bent B Vorum Henrik H

Acta ophthalmologica 20170328 7

<h4>Purpose</h4>The vertebrate retina contains a circadian clock participating in adaptations to day and night vision. This peripheral clock is independent of the master clock in the suprachiasmatic nucleus (SCN). The retinal clock is located in several cell types, including the photoreceptors. To investigate the role of the circadian clock of the photoreceptor cells in regulation of retinal protein rhythms, we analysed diurnal protein expression in the photoreceptor-deficient cone-rod homeobox ...[more]

PMID: 28371363

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