Dataset Information

Murine hippocampal phosphoproteome LC-MSMS

ABSTRACT: The hippocampus plays an important role in spatial memory and the conversion of short-term to long-term memory. Several studies have reported the presence of a peripheral oscillator in the hippocampus, and have highlighted the importance of circadian regulation in memory formation. In this study we performed global quantitative phosphoproteome analyses of the murine hippocampus across the circadian cycle, applying spiked-in labeled reference and high accuracy mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: kerwin chiang

LAB HEAD: Daniel Figeys

PROVIDER: PXD005669 | Pride | 2017-04-11

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Bo_20140321_hippo_phospho_1_FT.raw	Raw
	Bo_20140321_hippo_phospho_1_pH12.raw	Raw
	Bo_20140321_hippo_phospho_1_pH4.raw	Raw
	Bo_20140321_hippo_phospho_1_pH6.raw	Raw
	Bo_20140321_hippo_phospho_1_pH8.raw	Raw

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Publications

Phosphoproteome Profiling Reveals Circadian Clock Regulation of Posttranslational Modifications in the Murine Hippocampus.

Chiang Cheng-Kang CK Xu Bo B Mehta Neel N Mayne Janice J Sun Warren Y L WY Cheng Kai K Ning Zhibin Z Dong Jing J Zou Hanfa H Cheng Hai-Ying Mary HM Figeys Daniel D

Frontiers in neurology 20170322

The circadian clock is an endogenous oscillator that drives daily rhythms in physiology, behavior, and gene expression. The underlying mechanisms of circadian timekeeping are cell-autonomous and involve oscillatory expression of core clock genes that is driven by interconnecting transcription-translation feedback loops (TTFLs). Circadian clock TTFLs are further regulated by posttranslational modifications, in particular, phosphorylation. The hippocampus plays an important role in spatial memory ...[more]

PMID: 28382018

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