Transcriptomics

Dataset Information

0

Single-cell RNA sequencing of antigen specific CD4+ T cells induced by high vs low doses of MHC-II restricted neoantigens


ABSTRACT: Here, we report the impact of the dose of the MHC-II restricted neoantigens on the phenotypic and the effector function of tumor-specific CD4 T cells. Whereas vaccines containing low doses of MHC-II-restricted neoantigen (LDVax) generated helper CD4 T cells that promote the proliferation and the cytotoxic functions of CD8 T cells, vaccines containing high doses of MHC-II restricted neoantigen (HDVax) elicited type 1 regulatory T cells that suppress the antitumor immunity.

ORGANISM(S): Mus musculus

PROVIDER: GSE268301 | GEO | 2024/05/28

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-12-11 | GSE244992 | GEO
2017-03-27 | PXD005704 | Pride
2017-03-27 | PXD004746 | Pride
2024-01-31 | E-MTAB-13635 | biostudies-arrayexpress
2024-06-30 | E-MTAB-14130 | biostudies-arrayexpress
2024-05-22 | GSE268157 | GEO
2019-01-07 | PXD010808 | Pride
2021-11-02 | PXD029082 | Pride
2024-10-31 | GSE279137 | GEO
2024-05-28 | GSE268300 | GEO