Dataset Information

Human mesenchimal stem cells secretome

ABSTRACT: The study reports for the first time a quantitative proteomic characterization of the secretome of human bone marrow derived MSC before and after stimulation with a panel of pro-inflammatory cytokines.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell, Cell Culture

SUBMITTER: gabriella tedeschi

LAB HEAD: Gabriella Tedeschi

PROVIDER: PXD005746 | Pride | 2017-08-11

REPOSITORIES: Pride

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Proteomic analysis of the secretome of human bone marrow-derived mesenchymal stem cells primed by pro-inflammatory cytokines.

Maffioli Elisa E Nonnis Simona S Angioni Roberta R Santagata Fabiana F Calì Bianca B Zanotti Lucia L Negri Armando A Viola Antonella A Tedeschi Gabriella G

Journal of proteomics 20170721

Mesenchymal stem cells (MSC) represent an impressive opportunity in term of regenerative medicine and immunosuppressive therapy. Although it is clear that upon transplantation MSC exert most of their therapeutic effects through the secretion of bioactive molecules, the effects of a pro-inflammatory recipient environment on MSC secretome have not been characterized. In this study, we used a label free mass spectrometry based quantitative proteomic approach to analyze how pro-inflammatory cytokine ...[more]

PMID: 28739509

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