Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA360424
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Sperm
SUBMITTER: Yohann Couté
LAB HEAD: Virginie Brun
PROVIDER: PXD005863 | Pride | 2017-04-24
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
TH2B-Exp1_Ctrl.raw | Raw | |||
TH2B-Exp1_Pos.raw | Raw | |||
TH2B-Exp2_Ctrl.raw | Raw | |||
TH2B-Exp2_Pos.raw | Raw | |||
TH2B.pride.mgf.gz | Mgf |
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Barral Sophie S Morozumi Yuichi Y Tanaka Hiroki H Montellier Emilie E Govin Jérôme J de Dieuleveult Maud M Charbonnier Guillaume G Couté Yohann Y Puthier Denis D Buchou Thierry T Boussouar Fayçal F Urahama Takashi T Fenaille François F Curtet Sandrine S Héry Patrick P Fernandez-Nunez Nicolas N Shiota Hitoshi H Gérard Matthieu M Rousseaux Sophie S Kurumizaka Hitoshi H Khochbin Saadi S
Molecular cell 20170330 1
Histone replacement by transition proteins (TPs) and protamines (Prms) constitutes an essential step for the successful production of functional male gametes, yet nothing is known on the underlying functional interplay between histones, TPs, and Prms. Here, by studying spermatogenesis in the absence of a spermatid-specific histone variant, H2A.L.2, we discover a fundamental mechanism involved in the transformation of nucleosomes into nucleoprotamines. H2A.L.2 is synthesized at the same time as T ...[more]