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Human- lung squamous cell carcinoma LC-MS/MS Orbitrap Fusion

ABSTRACT: Integration of LC-MS/MS data links biological processes to fragmentation of tumor epithelia, and morphological marker that associates with decreased patient survival in lung squamous cell carcinoma

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

DISEASE(S): Lung Squamous Cell Carcinoma

SUBMITTER: ruben casanova

LAB HEAD: Alex Soltermann

PROVIDER: PXD006132 | Pride | 2017-05-15

REPOSITORIES: Pride

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Morphoproteomic Characterization of Lung Squamous Cell Carcinoma Fragmentation, a Histological Marker of Increased Tumor Invasiveness.

Casanova Ruben R Xia Daniel D Rulle Undine U Nanni Paolo P Grossmann Jonas J Vrugt Bart B Wettstein Reto R Ballester-Ripoll Rafael R Astolfo Alberto A Weder Walter W Moch Holger H Stampanoni Marco M Beck Andrew H AH Soltermann Alex A

Cancer research 20170331 10

Accurate stratification of tumors is imperative for adequate cancer management. In addition to staging, morphologic subtyping allows stratification of patients into additional prognostic groups. In this study, we used an image-based computational method on pan-cytokeratin IHC stainings to quantify tumor fragmentation (TF), a measure of tumor invasiveness of lung squamous cell carcinoma (LSCC). In two independent clinical cohorts from tissue microarrays (TMA: <i>n</i> = 208 patients) and whole se ...[more]

PMID: 28364001

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