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Ovarian high grade serous carcinoma ascites cell proteoms

ABSTRACT: Tumor cells, macrophages and T cells from high grade serous ovarian carcinoma from the ascites of patients undergoing primary surgery were analysed without culturing (ex vivo) via obitrap.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell, Melanocyte, Ovarian Surface Epithelial Cell, Ascites

DISEASE(S): Ovary Serous Adenocarcinoma

SUBMITTER: Florian Finkernagel

LAB HEAD: Rolf Mueller

PROVIDER: PXD006138 | Pride | 2017-11-17

REPOSITORIES: Pride

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			Action	DRS
	201600715_SJ_ThomasWorzfeld_OvaryCarcinoma_Pat120_Tcell_201.raw	Raw
	201600715_SJ_ThomasWorzfeld_OvaryCarcinoma_Pat120_Tcell_202.raw	Raw
	201600715_SJ_ThomasWorzfeld_OvaryCarcinoma_Pat120_Tcell_203.raw	Raw
	201600715_SJ_ThomasWorzfeld_OvaryCarcinoma_Pat120_Tcell_204.raw	Raw
	201600715_SJ_ThomasWorzfeld_OvaryCarcinoma_Pat120_Tcell_205.raw	Raw

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Publications

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment.

Worzfeld Thomas T Finkernagel Florian F Reinartz Silke S Konzer Anne A Adhikary Till T Nist Andrea A Stiewe Thorsten T Wagner Uwe U Looso Mario M Graumann Johannes J Müller Rolf R

Molecular & cellular proteomics : MCP 20171115 2

Ovarian cancer is characterized by early transcoelomic metastatic spread via the peritoneal fluid, where tumor cell spheroids (TU), tumor-associated T cells (TAT), and macrophages (TAM) create a unique microenvironment promoting cancer progression, chemoresistance, and immunosuppression. However, the underlying signaling mechanisms remain largely obscure. To chart these signaling networks, we performed comprehensive proteomic and transcriptomic analyses of TU, TAT, and TAM from ascites of ovaria ...[more]

PMID: 29141914

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