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Proteomic changes in HepaRG cells exposed to mycotoxins, part 2

ABSTRACT: Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after 24 hour expousre and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

SUBMITTER: Marie-Caroline Smith

LAB HEAD: Marie-Caroline Smith, Ph.D Student

PROVIDER: PXD006267 | Pride | 2017-12-13

REPOSITORIES: Pride

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			Action	DRS
	2017FebQEmycotoxininstrumentsequencefile.csv	Csv
	2017_Feb_16_MC_UWPR_QE_myco29.pep.xml	Pepxml
	2017_Feb_16_MC_UWPR_QE_myco29.raw	Raw
	2017_Feb_16_MC_UWPR_QE_myco30.pep.xml	Pepxml
	2017_Feb_16_MC_UWPR_QE_myco30.raw	Raw

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Publications

Differential impacts of individual and combined exposures of deoxynivalenol and zearalenone on the HepaRG human hepatic cell proteome.

Smith Marie-Caroline MC Timmins-Schiffman Emma E Coton Monika M Coton Emmanuel E Hymery Nolwenn N Nunn Brook L BL Madec Stéphanie S

Journal of proteomics 20171205

Numerous surveys have highlighted the natural co-occurrence of deoxynivalenol (DON) and zearalenone (ZEA) mycotoxins in food and feed. Nevertheless, data regarding cellular mechanisms involved in response to their individual and simultaneous exposures are lacking. In this study, in order to analyze how low mycotoxin doses could impact cellular physiology and homeostasis, proteomic profiles of proliferating human hepatic cells (HepaRG) exposed for 1h and 24h to low DON and ZEA cytotoxicity levels ...[more]

PMID: 29208510

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Proteomic changes in HepaRG cells exposed to mycotoxins

Project description:Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after only 1h exposure and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)

2017-12-13 | PXD005840 | Pride

Omics-characterization of tebufenpyrad effects on HepaRG : cell culture medium

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Expression data from LCM-captured Zea mays root cells after challenge with Meloidogyne incognita

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Omics-characterization of tebufenpyrad effects on liver cells

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Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification - GeneNote

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