Dataset Information

Mouse CSF Analyses of middle cerebral ischemic/reperfusion (CI/R) injury followed by Buyang Huanwu Decoction

ABSTRACT: Ischemic stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Buyang Huanwu decoction (BHD), a traditional Chinese medicine prescription, has long been used clinically for neurological recovery after stroke. Its molecular characteristics and related biomarkers for the therapeutic effect in cerebrospinal fluid (CSF) are yet to be explored. In this project, CSF was obtained from acute ischemic stroke induced mice by a middle cerebral ischemic/reperfusion (CI/R) injury. Proteomic and metabolomic analyses of CSF were performed using LC-MS/MS to define the neuroprotective effect of BHD and the related biomarkers.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: Wei-Chi Ku

LAB HEAD: Wei-Chi Ku

PROVIDER: PXD006342 | Pride | 2019-02-16

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	150702-YUAN-CSF_CB1-1-1.raw	Raw
	150702-YUAN-CSF_CB1-1-2.raw	Raw
	150702-YUAN-CSF_CB1-1-3.raw	Raw
	150702-YUAN-CSF_CB1-2-1.raw	Raw
	150702-YUAN-CSF_CB1-2-2.raw	Raw

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Publications

Combined proteomic and metabolomic analyses of cerebrospinal fluid from mice with ischemic stroke reveals the effects of a Buyang Huanwu decoction in neurodegenerative disease.

Hsu Wei-Hsiang WH Shen Yuh-Chiang YC Shiao Young-Ji YJ Kuo Ching-Hua CH Lu Chung-Kuang CK Lin Tai-Yuan TY Ku Wei-Chi WC Lin Yun-Lian YL

PloS one 20190115 1

Ischemic stroke is one of the most common causes of death worldwide and is a major cause of acquired disability in adults. However, there is still a need for an effective drug for its treatment. Buyang Huanwu decoction (BHD), a traditional Chinese medicine (TCM) prescription, has long been used clinically to aid neurological recovery after stroke. To establish potential clinical indicators of BHD efficacy in stroke treatment and prognosis, we conducted a combined proteomic and metabolomic analys ...[more]

PMID: 30645580

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