Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: zhou lianqi
LAB HEAD: Lianqi Zhou
PROVIDER: PXD006386 | Pride | 2018-10-24
REPOSITORIES: Pride
Liu Ge G Wang Kai K Kuang Shan S Cao Ruobing R Bao Li L Liu Rui R Liu Hongwei H Sun Chaomin C
Cell death & disease 20180607 6
Cancer cells rewire their metabolism to satisfy the demands of uncontrolled proliferation and survival. The reprogramming of lipid metabolism supports tumor growth, metastasis, and therapy-resistance. Therefore, targeting lipid metabolic reprogramming is a potential cancer treatment strategy. We recently isolated the novel natural triterpene GL22 from Ganoderma leucocontextum, a traditional Chinese medicine. Here, we show that GL22 significantly inhibits the growth of the liver cancer cell line ...[more]