Proteomics

Dataset Information

0

Quantitative Analysis of Global Proteome in human cell line


ABSTRACT: In total, 5,829 protein groups were identified, among which 4,470 proteins were quantified. The fold-change cutoff was set when proteins with quantitative ratios above 1.3 or below 0.77 are deemed significant. Among the quantified proteins, 12 proteins are up-regulated and 116 proteins are down-regulated in group H12vsCON, 19 proteins are up-regulated and 122 proteins are down-regulated in group H24vsCON, 23 proteins are up-regulated and 31 proteins are down-regulated in group H24vsH12.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: zhou lianqi  

LAB HEAD: Lianqi Zhou

PROVIDER: PXD006386 | Pride | 2018-10-24

REPOSITORIES: Pride

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Publications

The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death.

Liu Ge G   Wang Kai K   Kuang Shan S   Cao Ruobing R   Bao Li L   Liu Rui R   Liu Hongwei H   Sun Chaomin C  

Cell death & disease 20180607 6


Cancer cells rewire their metabolism to satisfy the demands of uncontrolled proliferation and survival. The reprogramming of lipid metabolism supports tumor growth, metastasis, and therapy-resistance. Therefore, targeting lipid metabolic reprogramming is a potential cancer treatment strategy. We recently isolated the novel natural triterpene GL22 from Ganoderma leucocontextum, a traditional Chinese medicine. Here, we show that GL22 significantly inhibits the growth of the liver cancer cell line  ...[more]

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