Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Velos, Orbitrap Fusion, Q Exactive HF
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Liver
DISEASE(S): Hepatocellular Carcinoma
SUBMITTER: Katarzyna Buczak
LAB HEAD: Martin Beck
PROVIDER: PXD007052 | Pride | 2018-01-24
REPOSITORIES: Pride
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Molecular & cellular proteomics : MCP 20180123 4
The interpatient variability of tumor proteomes has been investigated on a large scale but many tumors display also intratumoral heterogeneity regarding morphological and genetic features. It remains largely unknown to what extent the local proteome of tumors intrinsically differs. Here, we used hepatocellular carcinoma as a model system to quantify both inter- and intratumor heterogeneity across human patient specimens with spatial resolution. We defined proteomic features that distinguish neop ...[more]