Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell
SUBMITTER: Florian Erhard
LAB HEAD: Stefan Stevanović
PROVIDER: PXD007203 | Pride | 2018-04-05
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 12 |
Erhard Florian F Halenius Anne A Zimmermann Cosima C L'Hernault Anne A Kowalewski Daniel J DJ Weekes Michael P MP Stevanovic Stefan S Zimmer Ralf R Dölken Lars L
Nature methods 20180312 5
Ribosome profiling has been used to predict thousands of short open reading frames (sORFs) in eukaryotic cells, but it suffers from substantial levels of noise. PRICE (https://github.com/erhard-lab/price) is a computational method that models experimental noise to enable researchers to accurately resolve overlapping sORFs and noncanonical translation initiation. We experimentally validated translation using major histocompatibility complex class I (MHC I) peptidomics and observed that sORF-deriv ...[more]