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Human H. pylori induced TAK1/TAB1 interactomics

ABSTRACT: Study of dynamic changes in TAK1/TAB1 complex formation after H. pylori infection in human epithelial cells

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Thilo Kaehne

LAB HEAD: PD Dr. T. Kähne

PROVIDER: PXD007632 | Pride | 2017-12-06

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	16_07_14_Olga_13_02_black_TAB1.mgf	Mgf
	16_07_14_Olga_13_02_black_TAB1.pride.mgf.gz	Mgf
	16_07_14_Olga_13_02_black_TAK1.mgf	Mgf
	16_07_14_Olga_13_02_black_TAK1.pride.mgf.gz	Mgf
	16_07_14_Olga_13_02_black_TAK1_Hp20.mgf	Mgf

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Publications

Interactome analysis of transforming growth factor-β-activated kinase 1 in <i>Helicobacter pylori</i>-infected cells revealed novel regulators tripartite motif 28 and CDC37.

Sokolova Olga O Kähne Thilo T Bryan Kenneth K Naumann Michael M

Oncotarget 20180221 18

Transforming growth factor-β (TGFβ)-activated kinase 1 (TAK1) plays a central role in controlling the cellular pro-inflammatory response via the activation of the nuclear factor κB (NF-κB)- and mitogen-activated protein (MAP) kinases-dependent transcriptional programs. Here, we show that depletion of TAK1 and the TAK1-binding proteins TAB1 and TAB2 affects NF-κB, JNK and p38 phosphorylation and suppresses NF-κB activity in AGS cells infected with <i>Helicobacter pylori</i> or stimulated with the ...[more]

PMID: 29581850

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