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Identification of the Saccharomyces cerevisiae ZMP binders

ABSTRACT: 5′-phosphoribosyl-5-amino-4-imidazole carboxamide monophosphate (ZMP) is a metabolic intermediate of the de novo purine biosynthesis pathway. Its accumulation in several cell types from bacteria to human is associated with growth impairment. Identification of ZMP-binding proteins was performed to understand the molecular basis of ZMP toxicity. To assess the specificity of ZMP-binding proteins, an affinity chromatography approach was also applied to the closely related molecules AMP, SZMP (Succinyl-ZMP) and AICAR (5-amino-4-imidazole carboxamide ribonucleoside, also named Acadesine).

INSTRUMENT(S): LTQ Orbitrap, LTQ, Q Exactive

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Stephane Claverol

LAB HEAD: Benoit Pinson

PROVIDER: PXD007780 | Pride | 2018-11-21

REPOSITORIES: Pride

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			Action	DRS
	bp080627_01.RAW	Raw
	bp080627_01.msf	Msf
	bp080903.msf	Msf
	bp080903_01.RAW	Raw
	bp080903_02.RAW	Raw

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