Proteomics

Dataset Information

0

Characterisation of HMGB1 interactome in PNT2 prostate cells


ABSTRACT: HMGB1 and HMGB2 are members of the High Mobility Group (HMG) protein superfamily that contain a DNA binding domain (HMG-Box), and their overexpression has been related to main cancer hallmarks, tumor progression, metastasis formation and bad prognosis. We have used yeast two hybrid and affinity purification-mass spectrometry to explore HMGB1 and HMGB2 protein interactions in prostate and ovarian epithelial cells.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: James Wright  

LAB HEAD: Jyoti Choudhary

PROVIDER: PXD007867 | Pride | 2018-05-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
OT25cm_AB16B1.msf Msf
OT25cm_AB16B1.raw Raw
OT25cm_AB16Rb.msf Msf
OT25cm_AB16Rb.raw Raw
OT25cm_AB20B1.msf Msf
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Publications

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

Barreiro-Alonso Aida A   Lamas-Maceiras Mónica M   García-Díaz Rosa R   Rodríguez-Belmonte Esther E   Yu Lu L   Pardo Mercedes M   Choudhary Jyoti S JS   Cerdán María Esperanza ME  

Oncotarget 20180410 27


High Mobility Group B (HMGB) proteins are involved in cancer progression and in cellular responses to platinum compounds used in the chemotherapy of prostate and ovary cancer. Here we use affinity purification coupled to mass spectrometry (MS) and yeast two-hybrid (Y2H) screening to carry out an exhaustive study of HMGB1 and HMGB2 protein interactions in the context of prostate and ovary epithelia. We present a proteomic study of HMGB1 partners based on immunoprecipitation of HMGB1 from a non-ca  ...[more]

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