Dataset Information

Fibroblast activation - CTGF/VEGFA-activated fibroblasts promote tumor migration through micro-environmental modulation

ABSTRACT: The tumour secretome contains proteinaceous factors that could potentially cause activation of neighbouring fibroblasts via contact-independent processes. In this project, we aim to identify such paracrine activators of tumour origin and elucidate the functional impact of activation on fibroblasts and the tumour metastatic process.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Fibroblast

DISEASE(S): Breast Cancer

SUBMITTER: wei wu

LAB HEAD: Albert JR Heck

PROVIDER: PXD007898 | Pride | 2018-07-23

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	MQsearch_BSTactivatedSecretome.zip	Other
	MQsearch_HighPHproteome.zip	Other
	MQsearch_Phosphoproteome.zip	Other
	MQsearch_SecretomeDiscovery.zip	Other
	OR10_20150530_ww_phosphoA1-1.raw	Raw

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Publications

CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation.

Wu Wei W Zaal Esther A EA Berkers Celia R CR Lemeer Simone S Heck Albert J R AJR

Molecular & cellular proteomics : MCP 20180418 8

Fibroblast activation is associated with tumor progression and implicated in metastasis, but the initial triggering signals required to kick-start this process remain largely unknown. Because small cancerous lesions share limited physical contact with neighboring fibroblasts, we reasoned the first tumor-derived signal for fibroblast activation should be secreted and diffusible. By pulsed metabolic labeling and click-chemistry based affinity enrichment, we sieved through the ductal carcinoma secr ...[more]

PMID: 29669735

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