Dataset Information

Extracellular vesicles isolated from the descending colon of pediatric patients with inflammatory bowel disease and control patients

ABSTRACT: Characterizing the proteomic profile of extracellular vesicles isolated from the descending colon of pediatric patients with inflammatory bowel disease and control participants

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Colon

SUBMITTER: Shelley Deeke

LAB HEAD: Dr Daniel Figeys

PROVIDER: PXD007959 | Pride | 2018-09-11

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	MaxQuantOutput.tar.gz	Other
	Shelley_20160815_QE_EVesicles_514_dCA_UC_Mild.raw	Raw
	Shelley_20160815_QE_EVesicles_537_dCN_Control.raw	Raw
	Shelley_20160815_QE_EVesicles_568_dCA_CD_Mild.raw	Raw
	Shelley_20160815_QE_EVesicles_572_dCN_Control.raw	Raw

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Publications

Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease.

Zhang Xu X Deeke Shelley A SA Ning Zhibin Z Starr Amanda E AE Butcher James J Li Jennifer J Mayne Janice J Cheng Kai K Liao Bo B Li Leyuan L Singleton Ruth R Mack David D Stintzi Alain A Figeys Daniel D

Nature communications 20180720 1

Alterations in gut microbiota have been implicated in the pathogenesis of inflammatory bowel disease (IBD), however factors that mediate the host-microbiota interactions remain largely unknown. Here we collected mucosal-luminal interface samples from a pediatric IBD inception cohort and characterized both the human and microbiota proteins using metaproteomics. We show that microbial proteins related to oxidative stress responses are upregulated in IBD cases compared to controls. In particular, w ...[more]

PMID: 30030445

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