Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Fibroblast
SUBMITTER: Zon Weng Lai
LAB HEAD: Tobias Walther
PROVIDER: PXD007981 | Pride | 2022-02-15
REPOSITORIES: Pride
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SILAC_MEF_replicate1_wobvswt.raw | Raw | |||
SILAC_MEF_replicate1_wobvswt.zip | Other | |||
SILAC_MEF_replicate2_wtvswob.raw | Raw | |||
SILAC_MEF_replicate2_wtvswob.zip | Other | |||
SILAC_MEF_replicate3_wobvswt.raw | Raw |
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Proceedings of the National Academy of Sciences of the United States of America 20200428 19
Numerous mutations that impair retrograde membrane trafficking between endosomes and the Golgi apparatus lead to neurodegenerative diseases. For example, mutations in the endosomal retromer complex are implicated in Alzheimer's and Parkinson's diseases, and mutations of the Golgi-associated retrograde protein (GARP) complex cause progressive cerebello-cerebral atrophy type 2 (PCCA2). However, how these mutations cause neurodegeneration is unknown. GARP mutations in yeast, including one causing P ...[more]