Proteomics

Dataset Information

0

Dysregulation of the cGAS/STING axis due to COPI-deficiency


ABSTRACT: COPA syndrome is caused by mutations in the COP- subunit of coatomer protein complex 1 (COP-I), which participates in retrograde vesicular trafficking of proteins from the Golgi to the endoplasmic reticulum (ER). Disease manifests early in life with arthritis, lung disease, kidney dysfunction and systemic inflammation associated with NFB and type I interferon. We sought to identify the upstream innate immune sensor that drives inflammation in COPA syndrome.

INSTRUMENT(S): impact II

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Early Embryonic Cell, Kidney

SUBMITTER: Laura Dagley  

LAB HEAD: A/Prof Seth Masters

PROVIDER: PXD023135 | Pride | 2022-03-28

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
P3408_Ctrl_1_1_1_1_01_7674.d.zip Other
P3408_Ctrl_1_2_1_1_01_7675.d.zip Other
P3408_Ctrl_1_3_1_1_01_7676.d.zip Other
P3408_EV_1_1_1_1_01_7670.d.zip Other
P3408_EV_1_2_1_1_01_7671.d.zip Other
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