Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Keratinocyte, Skin
SUBMITTER: Fernando J. Sialana
LAB HEAD: Gert Lubec
PROVIDER: PXD008050 | Pride | 2019-05-27
REPOSITORIES: Pride
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EC06-HTkCtrl-BA1-P1144-1.raw | Raw | |||
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EC06-HTkCtrl-BA2-P1145-1.raw | Raw | |||
EC06-HTkCtrl-BA2-P1145-2.raw | Raw | |||
EC06-HTkCtrl-BA3-P1146-1.raw | Raw |
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Redox biology 20181113
Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators would be generated in primary human keratinocytes (KC) upon exposure to ultraviolet A light (UVA) and investigated the contribution of OxPL to UVA responses. Mass spectrometric analysis immediately or 24 h post UV stress revealed significant changes in abundance of 173 and 84 lipid species, respectively. We identified known and novel lipid ...[more]