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Proximity-proteomics-based autophagosome content profiling

ABSTRACT: proximity-proteomics-based autophagosome content profiling to identify a role for LC3C in maintaining basal mitochondrial homeostasis. Selected mitochondrial proteins, including MTX1, were targeted by LC3C and p62 through a piecemeal mitophagy pathway.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hela Cell

SUBMITTER: François Le Guerroué

LAB HEAD: Christian Behrends

PROVIDER: PXD008177 | Pride | 2018-02-28

REPOSITORIES: Pride

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			Action	DRS
	20151002_FLG_C-P1.raw	Raw
	20151002_FLG_C-P2.raw	Raw
	20151002_FLG_C-P3.raw	Raw
	20151002_FLG_C-P4.raw	Raw
	20151002_FLG_C-S1.raw	Raw

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Publications

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.

Le Guerroué François F Eck Franziska F Jung Jennifer J Starzetz Tatjana T Mittelbronn Michel M Kaulich Manuel M Behrends Christian C

Molecular cell 20171101 4

Autophagy allows the degradation of cytosolic endogenous and exogenous material in the lysosome. Substrates are engulfed by double-membrane vesicles, coined autophagosomes, which subsequently fuse with lysosomes. Depending on the involvement of specific receptor proteins, autophagy occurs in a selective or nonselective manner. While this process is well understood at the level of bulky cargo such as mitochondria and bacteria, we know very little about individual proteins and protein complexes th ...[more]

PMID: 29149599

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