Dataset Information

Systems toxicology assessment of CHTP1.2 [Lung Data]

ABSTRACT: Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. This study reports the results from the systems toxicology arm of a 90-day rat inhalation study (OECD test guideline 413) to assess the effects of CHTP1.2 aerosol compared with cigarette smoke (CS). Rats were exposed to filtered air (sham), to CHTP1.2 aerosol (at 15, 23 and 50 Âµg nicotine / L), or to the 3R4F reference cigarette smoke (at 23 Âµg nicotine / L).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Lung

SUBMITTER: Bjoern Titz

LAB HEAD: Julia Hoeng

PROVIDER: PXD008422 | Pride | 2018-03-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20161222_S150223__LL_90_42_set4_DR_PS_01.raw	Raw
	20161222_S150223__LL_90_42_set4_DR_PS_07.raw	Raw
	20161222_S150223__LL_90_42_set5_DR_PS_05.raw	Raw
	20161222_S150223__LL_90_42_set5_DR_PS_10.raw	Raw
	20161222_S150223__LL_90_42_set6_DR_PS_06.raw	Raw

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Publications

A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment.

Titz Bjoern B Kogel Ulrike U Martin Florian F Schlage Walter K WK Xiang Yang Y Nury Catherine C Dijon Sophie S Baumer Karine K Peric Dariusz D Bornand David D Dulize Remi R Phillips Blaine B Leroy Patrice P Vuillaume Gregory G Lebrun Stefan S Elamin Ashraf A Guedj Emmanuel E Trivedi Keyur K Ivanov Nikolai V NV Vanscheeuwijck Patrick P Peitsch Manuel C MC Hoeng Julia J

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180313

Modified risk tobacco products (MRTPs) have the potential to reduce smoking-related health risks. The Carbon Heated Tobacco Product 1.2 (CHTP1.2) is a potential MRTP that uses a pressed carbon heat source to generate an aerosol by heating tobacco. Here, we report the results from the systems toxicology arm of a 90-day rat inhalation study (OECD test guideline 413) to assess the effects of CHTP1.2 aerosol compared with cigarette smoke (CS). Transcriptomics, proteomics, and lipidomics analyses com ...[more]

PMID: 29545142

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