Arginine methylation, Cob1 - Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: 
Simone Schopper
LAB HEAD: Michael Lund Nielsen
PROVIDER: PXD008504 | Pride | 2018-04-30
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20171031_QE6_nLC12_SIS_Collab_Kessels_GFPIP_01.raw | Raw | |||
| MaxQuantOutput.tar.gz | Other |
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Publications
Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl.
Hou Wenya W Nemitz Sabine S Schopper Simone S Nielsen Michael Lund ML Kessels Michael Manfred MM Qualmann Britta B
Developmental cell 20180401 2
The complex architecture of neuronal networks in the brain requires tight control of the actin cytoskeleton. The actin nucleator Cobl is critical for neuronal morphogenesis. Here we reveal that Cobl is controlled by arginine methylation. Coprecipitations, coimmunoprecipitations, cellular reconstitutions, and in vitro reconstitutions demonstrated that Cobl associates with the protein arginine methyltransferase PRMT2 in a Src Homology 3 (SH3) domain-dependent manner and that this promotes methylat ...[more]
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