Proteomics

Dataset Information

0

T-cell protein half live - Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis


ABSTRACT: Determine half lives of proteins in T-cells using dynamic SILAC labeling

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell

SUBMITTER: Maria Faelth Savitski  

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD008630 | Pride | 2018-05-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
0305_F2_R1_P78191B01_SILAC3.raw.gz Raw
0305_F2_R1_P78191B02_SILAC3.raw.gz Raw
0305_F2_R1_P78191B03_SILAC3.raw.gz Raw
0305_F2_R1_P78191B04_SILAC3.raw.gz Raw
0305_F2_R1_P78191B05_SILAC3.raw.gz Raw
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Publications


Protein degradation plays important roles in biological processes and is tightly regulated. Further, targeted proteolysis is an emerging research tool and therapeutic strategy. However, proteome-wide technologies to investigate the causes and consequences of protein degradation in biological systems are lacking. We developed "multiplexed proteome dynamics profiling" (mPDP), a mass-spectrometry-based approach combining dynamic-SILAC labeling with isobaric mass tagging for multiplexed analysis of  ...[more]

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