Proteomics

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Quantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation.

ABSTRACT: Genetic and genomic research has greatly advanced our understanding of heart disease; yet a comprehensive map of the protein landscape of living human hearts is still lacking. Here we set out to identify the molecular basis of functional differences between human cardiac chambers by comprehensive protein expression quantification from samples collected in vivo by high-resolution mass spectrometry. Cardiac biopsies of right atria (RA), left atria (LA) and left ventricle (LV) were obtained from seven humans undergoing open chest surgery and analyzed by high-resolution mass spectrometry. We identify hundreds of proteins with a chamber specific expression pattern, supporting the different functional roles of the cardiac chambers, enabling identification of chamber specific drug targets, and offering novel links between genomic data and the mechanisms of disease.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart

SUBMITTER: Nora Linscheid  

LAB HEAD: Alicia Lundby

PROVIDER: PXD008722 | Pride | 2020-06-15

REPOSITORIES: Pride

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20160715_QE5_nLC7_NL_Human_Heart_097_Left_Atrium_Frac01.raw Raw
20160715_QE5_nLC7_NL_Human_Heart_097_Left_Atrium_Frac02.raw Raw
20160715_QE5_nLC7_NL_Human_Heart_097_Left_Atrium_Frac03.raw Raw
20160715_QE5_nLC7_NL_Human_Heart_097_Left_Atrium_Frac04.raw Raw
20160715_QE5_nLC7_NL_Human_Heart_097_Left_Atrium_Frac05.raw Raw
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Publications

Quantitative Proteomics of Human Heart Samples Collected <i>In Vivo</i> Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation.

Linscheid Nora N   Poulsen Pi Camilla PC   Pedersen Ida Dalgaard ID   Gregers Emilie E   Svendsen Jesper Hastrup JH   Olesen Morten Salling MS   Olsen Jesper Velgaard JV   Delmar Mario M   Lundby Alicia A  

Molecular & cellular proteomics : MCP 20200414 7

Genetic and genomic research has greatly advanced our understanding of heart disease. Yet, comprehensive, in-depth, quantitative maps of protein expression in hearts of living humans are still lacking. Using samples obtained during valve replacement surgery in patients with mitral valve prolapse (MVP), we set out to define inter-chamber differences, the intersect of proteomic data with genetic or genomic datasets, and the impact of left atrial dilation on the proteome of patients with no history  ...[more]

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