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Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance

ABSTRACT: Myopia (short-sightedness) affects approximately 1.4 billion people worldwide, many of whom will become blind from secondary ophthalmic conditions. The pathophysiology of myopia has been investigated by rearing young animals with monocular negative lenses or occluders that stimulate excessive ocular growth. Although a wide range of gene and protein expression changes have been identified in these myopia models, how these expression responses vary across different ocular growth conditions (including normal ocular development and hyperopia induced by positive lenses) remains poorly understood. Accordingly, this study has examined the trajectory of protein pathway expression shifts during normal development, and lens-induced myopia and hyperopia, in the widely used chick model.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Retinal Pigment Epithelium Cell

SUBMITTER: Pierre Faou

LAB HEAD: Pierre Faou

PROVIDER: PXD008818 | Pride | 2018-08-13

REPOSITORIES: Pride

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Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance.

Riddell Nina N Faou Pierre P Crewther Sheila G SG

BMC developmental biology 20180829 1

<h4>Background</h4>Myopia (short-sightedness) affects approximately 1.4 billion people worldwide, and prevalence is increasing. Animal models induced by defocusing lenses show striking similarity with human myopia in terms of morphology and the implicated genetic pathways. Less is known about proteome changes in animals. Thus, the present study aimed to improve understanding of protein pathway responses to lens defocus, with an emphasis on relating expression changes to no lens control developme ...[more]

PMID: 30157773

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