Proteomics

Dataset Information

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Proteomic characterization of plasma-derived exosomes from P. vivax infected FRG huHep mice


ABSTRACT: This project focused in the proteomic characterization of plasma-derived exosomes from Plasmodium vivax infected FRG huHep mice, a suitable in vivo model for the development of pre-erythrocytic stages of this parasite. P. vivax is responsible for the vast majority of Malaria cases outside Africa. This parasite evolved a latent liver stage form called hypnozoite that cannot be detected using the current diagnostic methods. This represent a major limitation to the Malaria elimination goal. Exosomes are extracellular vesicles involved in intercellular communication and in a large variety of physiological functions. Recently, this vesicles have been recognized for the immense potential to be used as biomarkers in the context of non-invasive diagnostic approaches from liquid biopsies. The exploration of the protein content of exosomes secreted into the bloodstream of P. vivax infected FRG huHep mice represents an interesting approach to tackle the big challenge of identifying a hypnozoite biomarker which in the future could help to identify hypnozoites carriers in Malaria vivax relapsing patients.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Plasmodium Vivax Mus Musculus (mouse)

TISSUE(S): Blood Plasma

DISEASE(S): Plasmodium Vivax Malaria

SUBMITTER: Hernando A del Portillo  

LAB HEAD: Hernando A del Portillo

PROVIDER: PXD008945 | Pride | 2018-07-16

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
160705_S_JSHP_19_01_1ug.raw Raw
160705_S_JSHP_20_01_1ug.raw Raw
160705_S_JSHP_hipnozoitos.msf Msf
160812_S_JSHP_01_01_1ug.raw Raw
160812_S_JSHP_02_01_1ug.raw Raw
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Publications


Exosomes are extracellular vesicles of endocytic origin containing molecular signatures implying the cell of origin; thus, they offer a unique opportunity to discover biomarkers of disease. <i>Plasmodium vivax</i>, responsible for more than half of all malaria cases outside Africa, is a major obstacle in the goal of malaria elimination due to the presence of dormant liver stages (hypnozoites), which after the initial infection may reactivate to cause disease. Hypnozoite infection is asymptomatic  ...[more]

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