Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, Synapt MS
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Bogdan Florea
LAB HEAD: Mario van der Stelt
PROVIDER: PXD008979 | Pride | 2018-04-19
REPOSITORIES: Pride
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20161014_NPC_DH1_M01.raw.zip | Raw | |||
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20161014_NPC_DH1_M03.raw.zip | Raw | |||
20161014_NPC_DH2_M01.raw.zip | Raw | |||
20161014_NPC_DH2_M02.raw.zip | Raw |
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Frontiers in neuroscience 20180703
The endocannabinoid system (ECS) is considered to be an endogenous protective system in various neurodegenerative diseases. Niemann-Pick type C (NPC) is a neurodegenerative disease in which the role of the ECS has not been studied yet. Most of the endocannabinoid enzymes are serine hydrolases, which can be studied using activity-based protein profiling (ABPP). Here, we report the serine hydrolase activity in brain proteomes of a NPC mouse model as measured by ABPP. Two ABPP methods are used: a g ...[more]