Proteomics

Dataset Information

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Phosphotyrosine profiling of human cerebrospinal fluid


ABSTRACT: Cerebrospinal Fluid (CSF) surrounds the brain and provides it protection inside the skull. It is also used clinically for diagnosis of neurological disorders as well as to monitor disease progression. Neurodegeneration in the brain is known to be associated with altered phosphorylation of proteins expressed in the brain. Most studies have focused on serine/threonine phosphorylation although identification of abnormally tyrosine phosphorylated proteins in CSF can similarly reveal additional biomarkers for neurodegenerative diseases. To achieve this goal, we carried out phosphotyrosine profiling of CSF using phosphotyrosine antibody-based enrichment and high resolution mass spectrometry.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: Akhilesh Pandey  

LAB HEAD: Akhilesh Pandey

PROVIDER: PXD009152 | Pride | 2022-02-23

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
Phospho_CSF_All_R12.msf Msf
Phospho_CSF_IP1_R1.raw Raw
Phospho_CSF_IP1_R2.raw Raw
Phospho_CSF_IP2_R1.raw Raw
Phospho_CSF_IP2_R2.raw Raw
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