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HDL proteome across 93 mouse strains

ABSTRACT: High-density lipoproteins (HDL) are nanoparticles with >80 associated proteins, phospholipids, cholesterol and cholesteryl esters. We have identified and quantified the ultracentrifugation isolated HDL proteome across 93 strains of mice, a diverse inbred strains of mice, Hybrid Mouse Diversity Panel (HMDP).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Nathalie Pamir

LAB HEAD: Nathalie Pamir

PROVIDER: PXD009473 | Pride | 2019-04-24

REPOSITORIES: Pride

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			Action	DRS
	151802_2HMDP145.raw	Raw
	151802_2HMDP146.raw	Raw
	151802_2HMDP147.raw	Raw
	151802_2HMDP148.raw	Raw
	151802_2HMDP149.raw	Raw

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Publications

Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity.

Pamir Nathalie N Pan Calvin C Plubell Deanna L DL Hutchins Patrick M PM Tang Chongren C Wimberger Jake J Irwin Angela A Vallim Thomas Q de Aguiar TQA Heinecke Jay W JW Lusis Aldons J AJ

Journal of lipid research 20190108 3

HDLs are nanoparticles with more than 80 associated proteins, phospholipids, cholesterol, and cholesteryl esters. The potential inverse relation of HDL to coronary artery disease (CAD) and the effects of HDL on myriad other inflammatory conditions warrant a better understanding of the genetic basis of the HDL proteome. We conducted a comprehensive genetic analysis of the regulation of the proteome of HDL isolated from a panel of 100 diverse inbred strains of mice (the hybrid mouse diversity pane ...[more]

PMID: 30622162

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