Proteomics

Dataset Information

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Identification of Acinetobacter baumannii AB307-0294 type VI secretion system secreted proteins


ABSTRACT: In order to identify secreted proteins associated with the type VI secretion system (T6SS), the secretome of a wild-type A. baumannii AB307 0294 T6SS active strain was compared to the secretome of a T6SS inactive mutant strain, A. baumannii AB307-0294ΔtssM.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Acinetobacter Baumannii

SUBMITTER: Ralf Schittenhelm  

LAB HEAD: John Boyce

PROVIDER: PXD009528 | Pride | 2018-05-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
F1RS20180207_JL_Tm_Plus_A.raw Raw
F1RS20180207_JL_Tm_Plus_B.raw Raw
F1RS20180207_JL_Tm_Plus_C.raw Raw
F1RS20180207_JL_WT_Plus_A.raw Raw
F1RS20180207_JL_WT_Plus_B.raw Raw
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Publications

Identification of Novel Acinetobacter baumannii Type VI Secretion System Antibacterial Effector and Immunity Pairs.

Fitzsimons Timothy C TC   Lewis Jessica M JM   Wright Amy A   Kleifeld Oded O   Schittenhelm Ralf B RB   Powell David D   Harper Marina M   Boyce John D JD  

Infection and immunity 20180723 8


The type VI secretion system (T6SS) is a macromolecular machine that delivers protein effectors into host cells and/or competing bacteria. The effectors may be delivered as noncovalently bound cargo of T6SS needle proteins (VgrG/Hcp/PAAR) or as C-terminal extensions of these proteins. Many <i>Acinetobacter baumannii</i> strains produce a T6SS, but little is known about the specific effectors or how they are delivered. In this study, we show that <i>A. baumannii</i> AB307-0294 encodes three <i>vg  ...[more]

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