Unknown,Transcriptomics,Genomics,Proteomics

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Characterization of A. baumannii Mitomycin C (MMC) response


ABSTRACT: Transcriptional profiling of A. baumannii ATCC 17978 comparing treated-MMC cultures with non-MMC treated cultures Two-condition experiment A. baumannii 17978 MMC+ vs A. baumannii 17978 MMC-. Biological replicates:3, Technical replicates:2

ORGANISM(S): Acinetobacter baumannii ATCC 17978

SUBMITTER: JESUS ARANDA 

PROVIDER: E-GEOD-44735 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of a DNA-damage-inducible regulon in Acinetobacter baumannii.

Aranda Jesús J   Poza Margarita M   Shingu-Vázquez Miguel M   Cortés Pilar P   Boyce John D JD   Adler Ben B   Barbé Jordi J   Bou Germán G  

Journal of bacteriology 20131011 24


The transcriptional response of Acinetobacter baumannii, a major cause of nosocomial infections, to the DNA-damaging agent mitomycin C (MMC) was studied using DNA microarray technology. Most of the 39 genes induced by MMC were related to either prophages or encoded proteins involved in DNA repair. Electrophoretic mobility shift assays demonstrated that the product of the A. baumannii MMC-inducible umuD gene (umuDAb) specifically binds to the palindromic sequence TTGAAAATGTAACTTTTTCAA present in  ...[more]

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