Proteomics,Multiomics

Dataset Information

0

Respiratory complex II - Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints


ABSTRACT: Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

OTHER RELATED OMICS DATASETS IN: PRJNA429204

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Xiaomin Song  

LAB HEAD: Mark Molloy

PROVIDER: PXD009656 | Pride | 2018-10-18

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
150527_P17769_Pooled_IDA_1.group Other
150527_P17769_Pooled_IDA_1.wiff Wiff
150527_P17769_Pooled_IDA_1.wiff.scan Wiff
150527_P17769_Pooled_IDA_All.txt Txt
150528_P17769_MB-231-SDHB-KO-shSDHA_swath_1.wiff Wiff
Items per page:
1 - 5 of 35
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Publications


Cell growth and survival depend on a delicate balance between energy production and synthesis of metabolites. Here, we provide evidence that an alternative mitochondrial complex II (CII) assembly, designated as CII<sub>low</sub>, serves as a checkpoint for metabolite biosynthesis under bioenergetic stress, with cells suppressing their energy utilization by modulating DNA synthesis and cell cycle progression. Depletion of CII<sub>low</sub> leads to an imbalance in energy utilization and metabolit  ...[more]

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