Proteomics

Dataset Information

0

Analysis of reversibly oxidized cysteines from the Chlamydomonas proteome with yeast spike-in


ABSTRACT: Benchmarking dataset for the objective evaluation of quantitative and statistical workflows.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Chlamydomonas Reinhardtii

SUBMITTER: Evan McConnell  

LAB HEAD: Leslie M. Hicks

PROVIDER: PXD009693 | Pride | 2019-03-19

REPOSITORIES: Pride

Dataset's files

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Publications

Evaluation of linear models and missing value imputation for the analysis of peptide-centric proteomics.

Berg Philip P   McConnell Evan W EW   Hicks Leslie M LM   Popescu Sorina C SC   Popescu George V GV  

BMC bioinformatics 20190314 Suppl 2


<h4>Background</h4>Several methods to handle data generated from bottom-up proteomics via liquid chromatography-mass spectrometry, particularly for peptide-centric quantification dealing with post-translational modification (PTM) analysis like reversible cysteine oxidation are evaluated. The paper proposes a pipeline based on the R programming language to analyze PTMs from peptide-centric label-free quantitative proteomics data.<h4>Results</h4>Our methodology includes variance stabilization, nor  ...[more]

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