Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Cervix Carcinoma
SUBMITTER: Magnus Jakobsson
LAB HEAD: Jesper V Olsen
PROVIDER: PXD009914 | Pride | 2018-07-04
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 23 |
Jakobsson Magnus E ME Małecki Jędrzej M JM Halabelian Levon L Nilges Benedikt S BS Pinto Rita R Kudithipudi Srikanth S Munk Stephanie S Davydova Erna E Zuhairi Fawzi R FR Arrowsmith Cheryl H CH Jeltsch Albert A Leidel Sebastian A SA Olsen Jesper V JV Falnes Pål Ø PØ
Nature communications 20180824 1
Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is subject to extensive post-translational methylation, but several of the responsible enzymes remain unknown. Using a wide range of experimental approaches, we here show that human methyltransferase (MTase)-like protein 13 (METTL13) contains two distinct MTase domains targeting the N terminus and Lys55 of eEF1A, respectively. Our biochemical and str ...[more]