Apolipoprotein A1 forms 5/5 and 5/4 antiparallel dimers in human high-density lipoprotein
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma
SUBMITTER: 
Yi He
LAB HEAD: Jay W Heinecke
PROVIDER: PXD009927 | Pride | 2019-04-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| APOA1dimers.xlsx | Xlsx | |||
| HDL_EDC_01.raw | Raw | |||
| HDL_EDC_02.raw | Raw | |||
| HDL_EDC_03.raw | Raw | |||
| HDL_EDC_04.raw | Raw |
Items per page: 5 1 - 5 of 31 |
Publications
Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein.
He Yi Y Song Hyun D HD Anantharamaiah G M GM Palgunachari M N MN Bornfeldt Karin E KE Segrest Jere P JP Heinecke Jay W JW
Molecular & cellular proteomics : MCP 20190118 5
Apolipoprotein A1 (APOA1), the major protein of high-density lipoprotein (HDL), contains 10 helical repeats that play key roles in protein-protein and protein-lipid interactions. The current structural model for HDL proposes that APOA1 forms an antiparallel dimer in which helix 5 in monomer 1 associates with helix 5 in monomer 2 along a left-left (LL5/5) interface, forming a protein complex with a 2-fold axis of symmetry centered on helix 5. However, computational studies suggest that other orie ...[more]
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