Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Monocyte, Chest Muscle
DISEASE(S): Inflammation
SUBMITTER: Christian Preisinger
LAB HEAD: Frank Tacke
PROVIDER: PXD009944 | Pride | 2019-01-24
REPOSITORIES: Pride
Action | DRS | |||
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MaxQuant_Output.zip | Other | |||
OR2_2018_03_09_FeH_d21_M25_new_1.raw | Raw | |||
OR2_2018_03_09_FeH_d21_M25_new_2.raw | Raw | |||
OR2_2018_03_09_FeH_d21_M25_new_3.raw | Raw | |||
OR2_2018_03_09_FeH_d21_M25_new_4.raw | Raw |
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JCI insight 20190124 2
Polypropylene meshes that are commonly used for inguinal hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages expressing high levels of inflammatory activation markers. In mice, mesh implantation by the onlay technique induced rapid and strong myeloid cell accumulation, without substantial attenuation for up to 90 days. Myeloi ...[more]