Proteomics

Dataset Information

0

Transcriptome and protein interaction profiling in cancer cells with mutations in histone H3.3


ABSTRACT: This entry contains proteome data extracted from co-immunoprecipitation of engineered H3F3A locus fused to GFP in HEK293 cell line, followed by PAGE separation, in-gel proteolytic digestion and LC-MS/MS identification.

OTHER RELATED OMICS DATASETS IN: PRJNA401867PRJNA396955

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney Epithelial Cell, Cell Culture

DISEASE(S): Bone Giant Cell Tumor

SUBMITTER: Anders Lindroth  

LAB HEAD: Anders Mikael Lindroth

PROVIDER: PXD009966 | Pride | 2018-11-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Lindroth_01.mgf Mgf
Lindroth_01.mzid.gz Mzid
Lindroth_01.pride.mgf.gz Mgf
Lindroth_01.pride.mztab.gz Mztab
Lindroth_01.raw Raw
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Publications


While transcription as regulated by histones and their post-translational modifications has been well described, the function of histone variants in this process remains poorly characterized. Potentially important insight into this process pertain to the frequently occurring mutations of H3.3, leading to G34 substitutions in childhood glioblastoma and giant cell tumor of the bone (GCTB). In this study, we have established primary cell lines from GCTB patients and used them to uncover the influen  ...[more]

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