Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Epithelial Cell
DISEASE(S): Non-small Cell Lung Carcinoma
SUBMITTER: Daniel Heim
LAB HEAD: Frederick Klauschen
PROVIDER: PXD009996 | Pride | 2018-07-02
REPOSITORIES: Pride
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International journal of cancer 20181108 3
Cancer precision medicine largely relies on knowledge about genetic aberrations in tumors and next-generation-sequencing studies have shown a high mutational complexity in many cancers. Although a large number of the observed mutations is believed to be not causally linked with cancer, the functional effects of many rare mutations but also of combinations of driver mutations are often unknown. Here, we perform a systems analysis of a model of EGFR-mutated nonsmall cell lung cancer resistant to t ...[more]