Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Hepatocellular Carcinoma
SUBMITTER: Dupuy Jean-William
LAB HEAD: Grosset Christophe
PROVIDER: PXD010085 | Pride | 2019-10-23
REPOSITORIES: Pride
Action | DRS | |||
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Linkbetweenfiles.xlsx | Xlsx | |||
RPS_2015_04_Homo_sapiens.fasta | Fasta | |||
fc150617_C1b.msf | Msf | |||
fc150617_C1b.raw | Raw | |||
fc150617_C2b.msf | Msf |
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Liver international : official journal of the International Association for the Study of the Liver 20191031 1
<h4>Background</h4>Therapeutic outcomes using the multikinase inhibitors, sorafenib and regorafenib, remain unsatisfactory for patients with advanced hepatocellular carcinoma (HCC). Thus, new drug modalities are needed. We recently reported the remarkable capacity of miR-4510 to impede the growth of HCC and hepatoblastoma through Glypican-3 (GPC3) targeting and Wnt pathway inactivation.<h4>Methods</h4>To identify new targets of miR-4510, we used a label-free proteomic approach and reported down- ...[more]