Dataset Information
Analysis of Plasmodium sporozoites collected from mosquito saliva
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive
ORGANISM(S): Anopheles Stephensi (asian Malaria Mosquito) Plasmodium Falciparum (isolate 3d7) Plasmodium Berghei Anka Anopheles Gambiae (african Malaria Mosquito)
TISSUE(S): Saliva
DISEASE(S): Malaria
SUBMITTER: 
Tyler Schleicher
LAB HEAD: Erol Fikrig
PROVIDER: PXD010121 | Pride | 2018-10-18
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| EDataQEp15-1266_AgPb_r_42788_1.raw.-1.mgf | Mgf | |||
| EDataQEp15-1268_AgPb_r_42788_2.raw.-1.mgf | Mgf | |||
| EDataQEp15-1360_AgPb.raw.-1.mgf | Mgf | |||
| EDataQEp15-1362_AgPb.raw.-1.mgf | Mgf | |||
| F490999.dat | Other |
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Publications
A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission.
Nature communications 20180725 1
The key step during the initiation of malaria is for motile Plasmodium parasites to exit the host dermis and infect the liver. During transmission, the parasites in the form of sporozoites, are injected together with mosquito saliva into the skin. However, the contribution of vector saliva to sporozoite activity during the establishment of the initial infection of the liver is poorly understood. Here we identify a vector protein by mass spectrometry, with similarity to the human gamma interferon ...[more]
