Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Aurelien Serandour
LAB HEAD: Jason Carroll
PROVIDER: PXD010312 | Pride | 2018-07-17
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
PR189_AUS_120412_JP289-01.msf | Msf | |||
PR189_AUS_120412_JP289-02.msf | Msf | |||
PR189_AUS_120412_JP289-03.msf | Msf | |||
PR189_AUS_120412_JP289-04.msf | Msf | |||
PR189_AUS_120412_JP289-05.msf | Msf |
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Oncogene 20180612 39
The chromatin state is finely tuned to regulate function and specificity for transcription factors such as oestrogen receptor alpha (ER), which contributes to cell growth in breast cancer. ER transcriptional potential is mediated, in large part, by the specific associated proteins and co-factors that interact with it. Despite the identification and characterisation of several ER coregulators, a complete and systematic view of ER-regulating chromatin modifiers is lacking. By exploiting a focused ...[more]