Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: Moritz Voelker-Albert
LAB HEAD: Prof. Dr. Axel Imhof
PROVIDER: PXD010424 | Pride | 2018-08-27
REPOSITORIES: Pride
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PeptideRatioresults.xlsx | Xlsx | |||
Ref1106_Moritz_FL_170301.raw | Raw | |||
Ref1106_Moritz_IS_PWWP_170301.raw | Raw | |||
Ref1106_Moritz_Input_170301.raw | Raw | |||
Ref1106_Moritz_PWWP_170301.raw | Raw |
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Nature communications 20181016 1
Chromatin structure and function is regulated by reader proteins recognizing histone modifications and/or histone variants. We recently identified that PWWP2A tightly binds to H2A.Z-containing nucleosomes and is involved in mitotic progression and cranial-facial development. Here, using in vitro assays, we show that distinct domains of PWWP2A mediate binding to free linker DNA as well as H3K36me3 nucleosomes. In vivo, PWWP2A strongly recognizes H2A.Z-containing regulatory regions and weakly bind ...[more]