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KIN interactome - Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin

ABSTRACT: BioID experiment of KIN protein to determine its interactors

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Christian Poitras

LAB HEAD: Benoit Coulombe

PROVIDER: PXD010487 | Pride | 2019-10-16

REPOSITORIES: Pride

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			Action	DRS
	VL_20151210_COU_01.mzid.gz	Mzid
	VL_20151210_COU_01.mzid_VL_20151210_COU_01.MGF	Mzid
	VL_20151210_COU_01.raw	Raw
	VL_20151210_COU_02.mzid.gz	Mzid
	VL_20151210_COU_02.mzid_VL_20151210_COU_02.MGF	Mzid

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Publications

Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.

Cloutier Philippe P Lavallée-Adam Mathieu M Faubert Denis D Blanchette Mathieu M Coulombe Benoit B

Journal of proteomics 20131016

Kin17 is a protein that was discovered through its immunoreactivity towards an antibody directed against prokaryotic RecA. Further study of Kin17 revealed a function in DNA replication and repair, as well as in pre-mRNA processing. Recently, it was found that Kin17 is methylated on lysine 135 by the newly discovered methyltransferase METTL22. To better understand the function of Kin17 and its regulation by methylation, we used multiple cell compartment protein affinity purification coupled with ...[more]

PMID: 24140279

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