Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human) Rattus Rattus (black Rat)
TISSUE(S): Spleen, Lung, Cell Culture
SUBMITTER: chuong nguyen
LAB HEAD: CHUONG NGUYEN
PROVIDER: PXD010606 | Pride | 2018-07-31
REPOSITORIES: Pride
Action | DRS | |||
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IB_evidence.txt | Txt | |||
IB_parameters.txt | Txt | |||
IB_peptides.txt | Txt | |||
IB_proteinGroups.txt | Txt | |||
NG_05262017_RAMOS_BTK_PF7014_PF7092_MS2REP1_01.raw | Raw |
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Proceedings of the National Academy of Sciences of the United States of America 20180716 31
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. They present an exciting opportunity to modulate proteins in a manner independent of enzymatic or signaling activity. As such, they have recently emerged as an attractive mechanism to explore previously "undruggable" targets. Despite this interest, fundamental questions remain reg ...[more]