Dataset Information

Necator americanus secretome - In the current project we have carried out the first proteogenomic analysis of a parasitic helminth

ABSTRACT: In the current project we have carried out the first proteogenomic analysis of a parasitic helminth. This has allowed us to significantly improve the genome annotation and provide a robust characterisation of the ES proteome from the adult N. americanus. Our findings show important information on key families of proteins with both known and unknown functions which may be instrumental for host-parasite interactions, parasite survival and immune regulation. Description of these proteins is useful for informing future identification of vaccine and drug targets, diagnostics and novel therapeutics for treating autoimmune and allergic diseases.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Necator Americanus

SUBMITTER: Javier Sotillo

LAB HEAD: Alex Loukas

PROVIDER: PXD010669 | Pride | 2019-09-26

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	Adult_ES_SDS_interact.comet.pep.xml	Pepxml
	Adult_ES_SDS_interact.tandem.pep.xml	Pepxml
	Adult_ES_SDS_iprophet.pep.mzid.gz	Mzid
	Adult_ES_SDS_iprophet.pep.xml	Pepxml
	Adult_ES_SDS_myfile.iproph.prot.xml	Xml

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1 - 5 of 373

Publications

Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms.

Logan Jayden J Pearson Mark S MS Manda Srikanth S SS Choi Young-Jun YJ Field Matthew M Eichenberger Ramon M RM Mulvenna Jason J Nagaraj Shivashankar H SH Fujiwara Ricardo T RT Gazzinelli-Guimaraes Pedro P Bueno Lilian L Mati Vitor V Bethony Jeffrey M JM Mitreva Makedonka M Sotillo Javier J Loukas Alex A

PLoS neglected tropical diseases 20200526 5

The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N. americanus live in the small intestine of the human host where they inject excretory/secretory (ES) products into the mucosa. ES products have been characterized at the proteome level for a number of animal hookworm species, but until now, the difficulty in obtaining sufficient live N. americanus has been an obstacle in characterizing th ...[more]

PMID: 32453752

Dataset Information

Necator americanus secretome - In the current project we have carried out the first proteogenomic analysis of a parasitic helminth

Dataset's files

Publications

Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms.

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