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A comparative quantitative LC-MS/MS profiling analysis of human pancreatic adenocarcinoma, adjacent-normal tissue, and patient-derived tumour xenografts

ABSTRACT: This study describes the comparative quantitative LC-MS/MS proteomic analysis of the membrane-enriched proteome of 10 human pancreatic ductal adenocarcinomas, 9 matched adjacent-normal pancreas and patient derived xenografts (PDX) in mice (10 at F1 generation and 10 F2).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Pancreatic Ductal Adenocarcinoma Cell, Epithelial Cell

DISEASE(S): Pancreatic Ductal Adenocarcinoma

SUBMITTER: Orla Coleman

LAB HEAD: Dr. Paula Meleady

PROVIDER: PXD010841 | Pride | 2025-01-17

REPOSITORIES: pride

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	10Nv10T.msf	Msf
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Publications

A Comparative Quantitative LC-MS/MS Profiling Analysis of Human Pancreatic Adenocarcinoma, Adjacent-Normal Tissue, and Patient-Derived Tumour Xenografts.

Coleman Orla O Henry Michael M O'Neill Fiona F Roche Sandra S Swan Niall N Boyle Lorraine L Murphy Jean J Meiller Justine J Conlon Neil T NT Geoghegan Justin J Conlon Kevin C KC Lynch Vincent V Straubinger Ninfa L NL Straubinger Robert M RM McVey Gerard G Moriarty Michael M Meleady Paula P Clynes Martin M

Proteomes 20181106 4

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide; it develops in a relatively symptom-free manner, leading to rapid disease progression and metastasis, leading to a 5-year survival rate of less than 5%. A lack of dependable diagnostic markers and rapid development of resistance to conventional therapies are among the problems associated with management of the disease. A better understanding of pancreatic tumour biology and discovery of new potential therapeutic t ...[more]

PMID: 30404163

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