Dataset Information

Repression of Human Papillomavirus Oncogene Expression under Hypoxia is Mediated by PI3K/mTORC2/AKT Signaling

ABSTRACT: Cornerstones of the regulatory phenomena observed in hypoxic HPV-positive cancer cells are: (i) hypoxia blocks E6/E7, an effect that can be counteracted by (ii) AKT inhibition and by (iii) high glucose supply. To gain further insights into the underlying regulatory circuits, mass spectrometry-based quantitative proteome analyses were performed comparing normoxic and hypoxic SiHa cells and assessing their response towards AKTi VIII and 25 mM glucose under hypoxia

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Cervix Carcinoma

SUBMITTER: Bianca Kuhn

LAB HEAD: Felix Hoppe-Seyler

PROVIDER: PXD011095 | Pride | 2019-02-18

REPOSITORIES: Pride

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			Action	DRS
	20180609_FS1_BK_1810_F065_R1_Fract1.raw	Raw
	20180609_FS1_BK_1810_F065_R1_Fract10.raw	Raw
	20180609_FS1_BK_1810_F065_R1_Fract11.raw	Raw
	20180609_FS1_BK_1810_F065_R1_Fract12.raw	Raw
	20180609_FS1_BK_1810_F065_R1_Fract2.raw	Raw

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Publications

Effects of Metformin on the virus/host cell crosstalk in human papillomavirus-positive cancer cells.

Hoppe-Seyler Karin K Herrmann Anja L AL Däschle Antonia A Kuhn Bianca J BJ Strobel Tobias D TD Lohrey Claudia C Bulkescher Julia J Krijgsveld Jeroen J Hoppe-Seyler Felix F

International journal of cancer 20210506 5

Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The viral E6/E7 oncogenes maintain the malignant growth of HPV-positive cancer cells. Targeted E6/E7 inhibition results in efficient induction of cellular senescence, which could be exploited for therapeutic purposes. Here we show that viral E6/E7 expression is strongly downregulated by Metformin in HPV-positive cervical cancer and head and neck cancer cells, both at the transcript and protein level. Metformin-induced ...[more]

PMID: 33844847

Publication: 1/2

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